| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1981865 | FEBS Open Bio | 2012 | 11 Pages |
Abstract
⸠We analyzed the epitope for the monoclonal antibody HCM31. ⸠HCM31 recognizes core 4 oligosaccharides with the Sda antigen obtained from small intestinal mucins of N. brasiliensis-infected rats. ⸠We propose that the Sda tetrasaccharide sequence, NeuAcα2-3(GalNAcβ1-4)Galβ1-4GlcNAcβ-, is the epitope for HCM31. ⸠Goblet cells stained with HCM31 decrease with malignant change in human colon tissues. ⸠HCM31 might be useful for the diagnosis of colonic cancer and for examining the function of mucin with Sda tetrasaccharide.
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Authors
Daigo Tsubokawa, Yukinobu Goso, Rei Kawashima, Hiroyoshi Ota, Takeshi Nakamura, Kazuo Nakamura, Noriko Sato, Makoto Kurihara, Taeko Dohi, Yuki I. Kawamura, Takafumi Ichikawa, Kazuhiko Ishihara,