Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1983425 | The International Journal of Biochemistry & Cell Biology | 2015 | 9 Pages |
Abstract
•Epo induced prolonged phosphorylation of proliferation signals in UT-7 cells.•cEpo induced only transient phosphorylation of proliferative pathways.•PTP1B activity was significantly increased in cultures with cEpo.•PTP1B colocalized with both subunits of the heterodimeric receptor used by cEpo.•Phosphatases are involved in the inability of cEpo to act as an erythroid growth factor.
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Authors
María Eugenia Chamorro, Romina Eugenia Maltaneri, Daniela Cecilia Vittori, Alcira Beatriz Nesse,