| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1983431 | The International Journal of Biochemistry & Cell Biology | 2015 | 9 Pages |
Abstract
- In this study, the hypoxia-induced model of pulmonary hypertension was employed.
- Hypoxia increases the expression of the microRNA family miR-130.
- miR-130 directly targets the tumor suppressor CDKN1A/p21 in vitro and in vivo.
- Decreased expression of CDKN1A/p21 contributes to right ventricular hypertrophy.
- Inhibition of miR-130 by seed blockers might offer novel therapeutic options.
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Authors
Matthias Brock, Thomas J. Haider, Johannes Vogel, Max Gassmann, Rudolf Speich, Michelle Trenkmann, Silvia Ulrich, Malcolm Kohler, Lars C. Huber,