Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1983581 | The International Journal of Biochemistry & Cell Biology | 2014 | 11 Pages |
Abstract
Recent studies in vertebrate model systems, from fishes to mammals and in human patients, have revealed complex and diverse loss-of-function phenotypes associated with mutations in components of the secretory machinery. A broad spectrum of diseases from skeletal and cardiovascular to neurological deficits have been linked to ECM trafficking. These discoveries have directly challenged the prevailing view of secretion as an essential but monolithic process. Here, we will discuss the latest findings on mechanisms of ECM trafficking in vertebrates.
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Authors
Gokhan Unlu, Daniel S. Levic, David B. Melville, Ela W. Knapik,