| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1983655 | The International Journal of Biochemistry & Cell Biology | 2013 | 5 Pages |
Abstract
The translocator protein (TSPO) is an 18 kDa transmembrane protein primarily found in the outer mitochondrial membrane where it forms a key part of the mitochondrial permeability transition pore (MPTP). Omnipresent in almost all tissues, TSPO up-regulation has been connected to neuronal damage and inflammation, making the protein an important bio-imaging marker for disease progression. More recently, TSPO has attracted attention as a possible molecular target for tumour imaging and chemotherapy. In this review we summarize TSPO's molecular characteristics and highlight research progress in recent years in the field of TSPO-targeted cancer diagnostics and treatments.
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Authors
Christopher J.D. Austin, Jan Kahlert, Michael Kassiou, Louis M. Rendina,