| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1983984 | The International Journal of Biochemistry & Cell Biology | 2012 | 4 Pages |
Abstract
⺠DNA topoisomerases II are enzymes which cleave both strands of DNA causing relaxation, decatenation and unknotting. ⺠In vertebrates there are two forms of topoisomerase II (α and β) with distinct functions. ⺠Topoisomerase IIα is necessary for cellular replication, while the β isoform is implicated mainly in transcription regulation and tissue differentiation.
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Authors
Anna Vávrová, TomáÅ¡ Å imůnek,