Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1983987 | The International Journal of Biochemistry & Cell Biology | 2012 | 4 Pages |
β-catenin is the central nuclear effector of the Wnt signaling pathway, and regulates other cellular processes including cell adhesion. Wnt stimulation of cells culminates in the nuclear translocation of β-catenin and transcriptional activation of target genes that function during both normal and malignant development. Constitutive activation of the Wnt pathway leads to inappropriate nuclear accumulation of β-catenin and gene transactivation, an important step in cancer progression. This has generated interest in the mechanisms regulating β-catenin nuclear accumulation and retention. Here we discuss recent advances in understanding feedback loops that trap β-catenin in the nucleus and provide potential insights into Wnt signaling and the development of anti-cancer drugs.