Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1984148 | The International Journal of Biochemistry & Cell Biology | 2011 | 5 Pages |
Abstract
The O-acetylation of peptidoglycan is now known to occur in 50 different bacterial species, both Gram positive and Gram negative, including a number of important human pathogens. This modification to the essential cell wall component of bacteria provides both a level of control over endogenous autolysins and protection from the lysozymes of innate immune systems. In this review, we describe the details of the pathways for peptidoglycan O-acetylation that are now beginning to emerge and we explore the possibility that the associated enzymes may present new candidates for antibacterial targets.
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Authors
Patrick J. Moynihan, Anthony J. Clarke,