| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1984568 | The International Journal of Biochemistry & Cell Biology | 2007 | 5 Pages |
Abstract
Virus-induced signaling adaptor (VISA) is essential for host innate immune responses against double-stranded RNA viral infection and viral replication. It is an adaptor that activates the transcription factors nuclear factor κB (NF-κB) and interferon regulatory factor 3 (IRF3) that regulate the expression of type I interferons. The localization of VISA to the outer membrane of mitochondria and the cellular consequences of its activation implicate this protein in the cellular etiology of neurodegenerative disorders.
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Authors
BaoChang Qi, Yue Huang, Dominic Rowe, Glenda Halliday,