| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1985085 | The International Journal of Biochemistry & Cell Biology | 2009 | 4 Pages |
Abstract
Monocyte chemoattractant protein-1 (MCP-1) is a potent chemoattractant for monocytes and macrophages to areas of inflammation. MCP-1 is a prototypical chemokine subject to coordinated regulation by immunomodulatory agents. Since MCP-1 is implicated in multiple inflammatory diseases, it is a potential target for the treatment of these disorders. In this review, we will provide background information and summarize the MCP-1 structure and signaling pathways. Its involvement in multiple diseases, such as tumour development, atherogenesis and rare autoimmune diseases is also revised.
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Authors
Esther Melgarejo, Miguel Ángel Medina, Francisca Sánchez-Jiménez, José Luis Urdiales,