| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1985203 | The International Journal of Biochemistry & Cell Biology | 2009 | 13 Pages |
Abstract
Taking into account the whole enzyme data and the functional test results, the described iso-APHAs showed a behaviour of class I/IIb HDACi, with 4b and 4i preferentially inhibiting class IIb and class I HDACs, respectively. When tested in the human leukaemia U937 cell line, 4i showed altered cell cycle (S phase arrest), joined to high (51%) apoptosis induction and significant (21%) differentiation activity.
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Authors
Antonello Mai, Sergio Valente, Angela Nebbioso, Silvia Simeoni, Rino Ragno, Silvio Massa, Gerald Brosch, Floriana De Bellis, Fabio Manzo, Lucia Altucci,