| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1985255 | The International Journal of Biochemistry & Cell Biology | 2008 | 11 Pages |
Abstract
PAI-1 is significantly downregulated in PASMC in IPAH, on the mRNA and protein level. PAI-1 negatively regulates PASMC proliferation, while it increases PASMC migration. Thus, its loss in IPAH may therefore contribute to pathologic vascular remodelling in IPAH.
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Authors
Fotini M. Kouri, Markus A. Queisser, Melanie Königshoff, Izabella Chrobak, Klaus T. Preissner, Werner Seeger, Oliver Eickelberg,