Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1985448 | The International Journal of Biochemistry & Cell Biology | 2007 | 6 Pages |
Abstract
Pancreatic duct cells secrete the HCO3â ions found in pancreatic juice. While the regulatory pathways that stimulate pancreatic ductal HCO3â secretion are well described, little is known about inhibitory pathways, apart from the fact that they exist. Nevertheless, such inhibitory pathways may be physiologically important in terms of limiting the hydrostatic pressure within the lumen of the duct, and in terms switching off pancreatic secretion after a meal. Methionine encephalin, insulin, somatostatin, peptide YY, substance P, basolaterally applied adenosine triphosphate, arginine vasopressin, 5-hydroxytryptamine and epidermal growth factor have all been shown to inhibit fluid and/or HCO3â secretion from pancreatic ducts. Importantly, most of these inhibitors have been shown to reduce secretion in isolated pancreatic ducts, so they must act directly on the ductal epithelium. This brief review provides an overview of our current knowledge of the inhibitors, and inhibitory pathways of pancreatic ductal secretion.
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Authors
Péter Hegyi, Zoltán Jr.,