Formulation design, preparation and characterization of multifunctional alginate stabilized nanodroplets

In vitro release profile of doxorubicin was an apparently biphasic release process and 7%-13% of drug released after 24 h incubation in PBS, pH = 7.4, depending on the nanodroplets composition but ultrasound exposure for 10 min resulted in triggered release of 85.95% of doxorubicin from optimal formulation (formulation E1 with 39.2 nm diameter size and 92.2% entrapment efficiency).