Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1986225 | International Journal of Biological Macromolecules | 2016 | 6 Pages |
Abstract
Oxidized celluloses have been used for decades as antimicrobial wound gauzes and surgical cotton. We now report the successful synthesis of a next generation narrow size range (25-35 nm) spherical shaped nanoparticles of 2,3,6-tricarboxycellulose based on cellulose I structural features, for applications as new antimicrobial materials. This study adds to our previous study of 6-carboxycellulose. A wide range of bacteria such as Escherichia coli, Staphloccocus aureus, Bacillus subtilis and Mycobacterium tuberculosis (non-pathogenic as well as pathogenic strains) were affected by these polymers in in vitro studies. Activity against Mycobacteria were noted at high concentrations (MIC99 values 250-1000 μg/ml, as compared to anti-TB drug Isoniazid 0.3 μg/ml). However, the broad spectrum activity of oxidized celluloses and their nanoparticles against a wide range of bacteria, including Mycobacteria, show that these materials are promising new biocompatible and biodegradable drug delivery vehicles wherein they can play the dual role of being a drug encapsulant as well as a broad spectrum anti-microbial and anti-TB drug.
Keywords
AFM6-CarboxycelluloseTCCATCCMICB. subtilisBacillus subtilisCFUE. coliDLSS. aureusEscherichia coliTemMinimal inhibition concentrationdegree of polymerizationCelluloseAnti-microbialAmerican Type Culture CollectionSEMScanning electron microscopyTransmission electron microscopyatomic force microscopyNanoparticlesSpherical nanoparticlesnanometercolony forming unitsDynamic Light Scatteringoptical density
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Authors
Priyanka R. Sharma, Sunil Kamble, Dhiman Sarkar, Amitesh Anand, Anjani J. Varma,