| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1986561 | International Journal of Biological Macromolecules | 2014 | 8 Pages |
•Ag-g-PAM was synthesized by ‘microwave assisted method’.•Synthesized grades were studied as matrix for controlled drug delivery at various pH.•Higher the percentage grafting lower is the rate of drug release.•Release of the drug from this grafted agar matrix is low in acidic pH and is much higher in neutral pH.•From the kinetics study, the drug release from Ag-g-PAM matrix follows Fickian release.
Agar has been modified by microwave assisted grafting with acrylamide monomer, resulting in poly acrylamide grafted agar (Ag-g-PAM). The synthesized grades of Ag-g-PAM were characterized by standard physico-chemical characterization techniques (FTIR spectroscopy, elemental analysis, scanning electron microscopy (SEM)) to ascertain the intended grafting. The synthesized graft copolymer (Ag-g-PAM) has been investigated (in vitro) for controlled and colon targeted release of 5-amino salicylic acid (5-ASA).
