| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1986783 | International Journal of Biological Macromolecules | 2013 | 7 Pages |
Surface confined interaction of anti-cancer drug bleomycin (BLM) with nucleic acids: single stranded and double stranded DNA was investigated herein by using electrochemical impedance spectroscopy (EIS) technique in combination with a graphite sensor technology. The experimental conditions were optimized: such as, dsDNA concentration, BLM concentration and interaction time. The main features of impedimetric DNA biosensor, such as its detection limit and the repeatability, were also discussed. The in situ interaction of BLM with dsDNA was also tested impedimetrically in the absence or presence of other chemotherapeutic agents, such as mitomycin C (MC) and cis-platin (cis-DDP) for testing the selectivity.
Graphical abstractSurface confined interaction of anti-cancer drug bleomycin (BLM) with double stranded DNA was investigated by using electrochemical impedance spectroscopy (EIS) technique in combination with a graphite sensor technology.Figure optionsDownload full-size imageDownload as PowerPoint slide
