Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1986803 | International Journal of Biological Macromolecules | 2013 | 9 Pages |
Abstract
The endogenous deposition of protein aggregates with fibrillar morphology is known to govern the genesis of several neurodisorders. The investigation of naturally occurring small molecules which can restrict the fibrillation process can help in the design of rational therapeutics for neurodegenerative diseases. We report the inhibition of HSA fibrillation in the presence of naturally occurring sugars such as glucose, fructose, ribose and sucrose with fructose being the most potent. We have characterized the inhibitory potency of the sugars, using different spectroscopic and microscopic techniques.
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Authors
Nitin K. Pandey, Sudeshna Ghosh, Swagata Dasgupta,