| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1986924 | International Journal of Biological Macromolecules | 2013 | 6 Pages |
Abstract
The porous branched dextran of molecular mass 2.93 × 105 Da with 50% overall yield (4.5 mg/ml) was produced from Pediococcus pentosaceus CRAG3 (GenBank ID: JX679020), a novel isolate from fermented cucumber. It contained glucose monomers linked through 75% α-(1,6) linkage with 25% (α-1,3) branching as displayed by spectroscopic analysis. The peak analysis showed α-(1,3) branching after every five glucose units of main chain. In vitro cytotoxicity analysis of dextran displayed anti-cancer activity against cervical cancer (HeLa) and colon cancer (HT29) cell lines opening new horizons in its pharmaceutical applications. Dextran showed enhanced growth of macrophage lines revealing its biocompatible nature.
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Authors
Rishikesh Shukla, Arun Goyal,