| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1987262 | International Journal of Biological Macromolecules | 2011 | 12 Pages |
Abstract
A nano formulation of curcumin loaded biodegradable thermoresponsive chitosan-g-poly (N-isopropylacrylamide) co-polymeric nanoparticles (TRC-NPs) (150 nm) were prepared by ionic cross-linking method and characterized. The in vitro drug release was prominent at above LCST. Cytocompatibility of TRC-NPs (100–1000 μg/ml) on an array of cell line is proved by MTT assay. The drug loaded TRC-NPs showed specific toxicity on cancer cells. The cell uptake studies were confirmed by fluorescent microscopy. Flowcytometric analysis of curcumin loaded TRC-NPs showed increased apoptosis on PC3 cells. These results indicated that TRC-NPs could be a potential nanovehicle for curcumin drug delivery.
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Authors
N. Sanoj Rejinold, P.R. Sreerekha, K.P. Chennazhi, S.V. Nair, R. Jayakumar,