Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1987316 | International Journal of Biological Macromolecules | 2009 | 5 Pages |
Abstract
A chemically sulfated galactomannan (BRS) from seeds of Mimosa scabrella had in vitro antiviral activity against Herpes simplex virus 1 (HSV-1), but not against Simian rotavirus A/SA11 (SiRV-A/SA11). It was examined by 13C NMR spectroscopy, which showed the sulfate groups to be mainly at C-6 of galactose residues. BRS had a selective inhibition against HSV-1 during its attachment step, having an IC50 lower than 2.5 μg/ml, determined by plaque reduction, and a selectivity index of greater than 181, suggesting that the antiviral effect is likely due to interactions between the virus and BRS, being influenced its overall surface charge.
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Authors
Francielli Chrestani, Maria Rita Sierakowski, Daniel Esdras de Andrade Uchoa, Carlos Nozawa, Guilherme Lanzi Sassaki, Philip Albert James Gorin, Lucy Ono,