Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1987507 | International Journal of Biological Macromolecules | 2009 | 7 Pages |
Abstract
Hyaluronic acid (HA) was added into fibroin solution to prepare fibroin-based porous composite scaffolds. HA exhibited important effects on pore formation and hydrophilicity of fibroin-based scaffold. The aqueous-fibroin/HA scaffolds had highly homogeneous and interconnected pores with porosity of above 90% and controllable pore size ranging from 123 to 253 μm. The water take-up of fibroin/HA scaffolds increased significantly with the increase of HA content. Containing HA at a defined content range, such as 3–6%, fibroin-based scaffolds’ affinity to primary neural cells was improved. In 6%HA/fibroin scaffolds, neurosphere-forming cell migrated from their original aggregate and adhered tightly to the surface of scaffolds.
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Authors
Yong-Juan Ren, Zi-You Zhou, Bing-Fang Liu, Qun-Yuan Xu, Fu-Zhai Cui,