Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1987631 | International Journal of Biological Macromolecules | 2009 | 5 Pages |
Abstract
A polysaccharide was isolated from marine green algae Monostroma latissimum, and its chemical characteristic and anticoagulant activity were investigated. The results demonstrated that the polysaccharide was high rhamnose-containing sulfated polysaccharide, and was mainly composed of 1,2-linked l-rhamnose residues with sulfate groups substituted at positions C-3 and/or C-4. The sulfated polysaccharide exhibited high anticoagulant activities by assays of the activated partial thromboplastin time (APTT) and thrombin time (TT). The anticoagulant property of the sulfated polysaccharide was mainly attributed to powerful potentiation thrombin by heparin cofactor II.
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Authors
Wenjun Mao, Hongyan Li, Yi Li, Huijuan Zhang, Xiaohui Qi, Haihong Sun, Yin Chen, Shoudong Guo,