Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1987636 | International Journal of Biological Macromolecules | 2009 | 9 Pages |
Abstract
It is well accepted that porphyrins related to heme, are effectively able to act as pharmaceutical. For instance, they were found to interfere with the aggregation of β-amyloid peptide. In present study, the influence of heme concentration on the amyloid-type aggregation of ovalbumin was investigated. We provided experimental evidence of heme's prevention of ovalbumin aggregation in the heat-denaturation process using spectroscopic measurements. Different types of interactions were suggested to be involved in heme-ovalbumin amyloid communication. Since the consequence of heme-attenuated fibrillogenesis is yet to be identified, additional data on chaperoning role of heme may help us to manage amyloid aggregation processes.
Keywords
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Biochemistry
Authors
Reza Khodarahmi, Hosnieh Soori, Seyyed Arash Karimi,