Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1987652 | International Journal of Biological Macromolecules | 2008 | 7 Pages |
Abstract
The Notch signaling pathway (NSP) is an important intercellular communication mechanism that regulates embryo development and adult physiological functions. The Hairless (H) protein is a powerful antagonist of the NSP by its interaction with the Suppressor of Hairless (Su[H]) protein, recruiting the corepressors Gro and CtBP. In the present work, we examined the role of several important amino acids in different H protein domains analyzing four mutant lines of Drosophila melanogaster. The mutant alleles were evaluated by single-strand conformational polymorphism (SSCP) analysis and we located mutated regions at different positions along the sequence of the Hairless gene.
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Authors
Daniel Paz-Gómez, Víctor Manuel Baizabal-Aguirre, Juan José Valdez-Alarcón, Marcos Cajero-Juárez, Anja C. Nagel, Anette Preiss, Dieter Maier, Alejandro Bravo-Patiño,