Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1987747 | International Journal of Biological Macromolecules | 2008 | 5 Pages |
Abstract
Taspine solid lipid nanoparticles (Ta-SLN) and taspine solid lipid nanoparticles modified by galactoside (Ta-G2SLN) were prepared by the film evaporation-extrusion method. The nanoparticles were spherical or near-spherical particles with smooth surface, small size and high encapsulation efficiency. Ta-G2SLN and Ta-SLN showed significant inhibition on 7721 cell growth. Intravenous injection of either Ta-SLN or Ta-G2SLN resulted in a higher plasma and liver concentration and a longer retention time in mice compared with the administration of Ta. These results suggested that SLN tended to be preferentially delivered to the liver and Ta-G2SLN may further enhance liver targeting.
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Authors
Wen Lu, Lang Chong He, Chang He Wang, Yan Hua Li, San Qi Zhang,