| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1988558 | Journal of Biochemical and Biophysical Methods | 2007 | 9 Pages |
Abstract
In this work the applicability of micellar elektrokinetic capillary chromatography (MECC) for the determination of benzodiazepines (BZD) has been studied. The applied method was used for the simultaneous separation of 8 BZDs (alprazolam, bromazepam, chlordiazepoxide, diazepam, flunitrazepam, medazepam, oxazepam, nitrazepam), and also for the study of stability in acidic medium. A fast and reliable method has been developed; using a separation buffer composed of sodium tetraborate 25 mM (pH 9.5), SDS (50 mM) and methanol (at least 12%) as an organic modifier.
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Authors
Gabriel Hancu, Attila Gáspár, Árpád Gyéresi,