Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1989568 | The Journal of Nutritional Biochemistry | 2016 | 8 Pages |
Abstract
In vivo, FGF21 responds acutely to LPHC intake whereas under an HPLC diet, plasma FGF21 circulating levels are low in the fasted and refed states. In hepatocytes, Fgf21 expression was controlled by glucose but not amino acids. Both diets increased the thermic effect of feeding (TEF) and ketogenesis was increased in fasted HPLC mice. The results presented suggest that dietary glucose, rather than amino acids, directly controls FGF21 secretion, and that FGF21 may be involved in the increased TEF response to LPHC. The effects of the HPLC diet on ketogenesis and TEF are probably controlled by other metabolic pathways.
Keywords
BATThermic effect of feedingAEEUCPFGF21TEFRMRCpt1aACCFASPOXResting metabolic rateacetyl-CoA carboxylaseAmino acidsfatty acid synthaseLipid oxidationProtein oxidationGlucose oxidationLOXbrown adipose tissueGoxfibroblast growth factor 21PhysiologyUncoupling proteincarnitine palmitoyltransferase 1aHPLCCalorimetryGlucose
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Tristan Chalvon-Demersay, Patrick C. Even, Daniel Tomé, Catherine Chaumontet, Julien Piedcoq, Claire Gaudichon, Dalila Azzout-Marniche,