Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1989589 | The Journal of Nutritional Biochemistry | 2016 | 9 Pages |
Abstract
Obesity is characterized by iron deficiency, carbohydrate and fat alterations as well as oxidative stress. Iron status monitoring is recommended because of the conventional oral iron preparations that frequently exacerbate the already present oxidative stress. Iron complexation by natural antioxidants can be exploited. We herein investigated the metabolic effects of quercetin (25Â mg/kg/day), iron (2.5Â mg Fe/kg/day) or quercetin-iron complexes (molar ratio 5:1; 25Â mg/2.5Â mg/kg/day) in animal models of obesity. Our results emphasized that obese rats displayed metabolic alterations that were worsened by iron supplementation. In contrast, quercetin used alone or as iron complex clearly prevented adipose fat accumulation and alleviated the hyperglycemia, hyperlipidemia, liver steatosis and oxidative stress. In addition, it induced a modulation of lipase activities in obese rats. Interestingly, quercetin-iron complexes showed enhanced beneficial effects such as a corrected iron deficiency in obese rats when compared to quercetin alone. In conclusion, antianemic, hypoglycemic, hypolipidemic and antioxidative effects of the quercetin-iron complexes shed a light on their beneficial use against obesity-related metabolic alterations.
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Authors
Asmahan Imessaoudene, Hafida Merzouk, Farid Berroukeche, Nassima Mokhtari, Bachir Bensenane, Sabri Cherrak, Sid Ahmed Merzouk, Mourad Elhabiri,