| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1989614 | The Journal of Nutritional Biochemistry | 2016 | 8 Pages |
Abstract
To assess the interaction between dietary and emotional stresses, we measured in brain mitochondria of insulin resistant rats: Ca2+retention capacity, respiration, ROS, enzymatic activities and signaling parameters. Stress delayed (43 %) the opening of mPTP by the Ca2+. The cafeteria diet dramatically decreased the amount of Ca2+ (13%) required to open the mPTP under stress, but cinnamon resulted in a partial recovery (30%). Antioxidant properties or targets on the PI3K-AKT-GSK3β and MAPK-P38 pathways might be involved in this corrective effect of cinnamon.87
Keywords
MPTPP/TDCIPPI3-KDNPAMPKC/SAcute stressPermeability transition poremitochondrial permeability transition poreCSAdichloroindophenoldinitrophenolRotRotenoneelectron transport chainCyclosporine Acalcium retention capacityPhosphatidylinositol 3-kinaseBrainInsulin resistanceMitochondriaETcadenosine monophosphate-activated protein kinasePolyphenolsCRCControlglycogen synthase kinase 3 beta
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Authors
Karine Couturier, Isabelle Hininger, Laurent Poulet, Richard A. Anderson, Anne-Marie Roussel, Frédéric Canini, Cécile Batandier,