| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1991716 | The Journal of Steroid Biochemistry and Molecular Biology | 2013 | 8 Pages |
Abstract
⺠Somatostatin analogs suppressed FSH-induced steroidogensis by rat granulosa cells. ⺠Pasireotide effect was more potent than that of octreotide. ⺠Blockade of BMP actions reversed somatostatin effects. ⺠SSTR activity modulates steroidogenesis by upregulating BMP activity.
Keywords
SSTR3β-Hydroxysteroid dehydrogenaseP450arom3βHSDFSHRP450sccPCOSactivin type-I receptorActRIIactivin type-II receptorBMPRIBMPRIIBMP type-I receptorBMP type-II receptorforskolinFskTGF-βP450 steroid side-chain cleavage enzymeP450 aromataseALKSteroidogenesisActRItransforming growth factor-βoocyteStargranulosa cellsPolycystic ovary syndromeSomatostatinfollicle-stimulating hormone (FSH)BMPfollicle-stimulating hormoneFSHSteroidogenic acute regulatory proteinBone morphogenetic proteinbone morphogenetic protein (BMP)activin receptor-like kinaseFSH receptorSomatostatin receptor
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Eri Nakamura, Fumio Otsuka, Kenichi Inagaki, Naoko Tsukamoto, Kanako Ogura-Ochi, Tomoko Miyoshi, Kishio Toma, Masaya Takeda, Hirofumi Makino,