Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1991752 | The Journal of Steroid Biochemistry and Molecular Biology | 2012 | 7 Pages |
Abstract
⺠Trihydroxynaphthalene reductase converts substrates with two rings, like DDBO. ⺠17β-Hydroxysteroid dehydrogenase converts four-ring substrates, like steroids. ⺠17β-HSDcl Ala231Trp mutant better reduces PQ and shows low conversion of steroids. ⺠3HNR Trp227Ala mutant better converts steroids and PQ, and less DDBO. ⺠Ala231 in 17β-HSDcl and Trp227 in 3HNR affect binding of larger/smaller substrates.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Mojca Brunskole Švegelj, Jure Stojan, Tea Lanišnik Rižner,