Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1991929 | The Journal of Steroid Biochemistry and Molecular Biology | 2009 | 6 Pages |
Abstract
The mechanisms of action of estradiol in the nervous system involve nuclear-initiated steroid signaling and membrane-initiated steroid signaling. Estrogen receptors (ERs) are involved in both mechanisms. ERα interacts with the signaling of IGF-1 receptor in neural cells: ERα transcriptional activity is regulated by IGF-1 receptor signaling and estradiol regulates IGF-1 receptor signaling. The interaction between ERα and the IGF-1 receptor in the brain may occur at the plasma membrane of neurons and glial cells. Caveolin-1 may provide the scaffolding for the interaction of different membrane-associated molecules, including voltage-dependent anion channel, ERα and IGF-I receptor.
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Authors
Raquel Marin, Mario Díaz, Rafael Alonso, Amaya Sanz, María Angeles Arévalo, Luis M. Garcia-Segura,