| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1992246 | The Journal of Steroid Biochemistry and Molecular Biology | 2007 | 13 Pages |
Abstract
Clinical response was assessable in 52 patients; 37 (71%) tumours were classified as clinical responders (>50% reduction in volume at 3 months). Microarray analysis of pre- and 14-day biopsies identified 291 covariates (84 baselines, 72 14-day and 135 changes) highly predictive of response status. A similarity matrix using the covariates showed responding tumours have a similar genetic profile which was dissimilar to non-responding cancers whereas non-responsive cases were distinctive from each other. Changed genes predicting for response showed no concordance with those changed significantly by treatment in the overall group.
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Authors
William R. Miller, Alexey Larionov, Lorna Renshaw, Thomas J. Anderson, Sharon White, Garret Hampton, John R. Walker, Steven Ho, Andreas Krause, Dean B. Evans, J. Michael Dixon,