Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1992379 | The Journal of Steroid Biochemistry and Molecular Biology | 2006 | 9 Pages |
Abstract
The results show that the tissue endocrine environment is affected by trilostane treatment in the absence of sustained changes in circulating corticosteroid. The combination of increased 11β-HSD2 and reduced GR expression in target organs could be expected to ameliorate the effects of excess glucocorticoid, suggesting new therapeutic approaches.
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Authors
S.D.M. Malouitre, S. Barker, J.R. Puddefoot, J. Jalili, H.R. Glover, G.P. Vinson,