Article ID Journal Published Year Pages File Type
1992520 The Journal of Steroid Biochemistry and Molecular Biology 2007 9 Pages PDF
Abstract

Three new Vitamin D analogs 3–5 incorporating a –CHF2 group as an –OH surrogate have been prepared. Two of these new analogs (3 and 5) are strongly antiproliferative toward murine keratinocytes and are approximately 50 times less calciuric in vivo than the natural hormone calcitriol. The transcriptional activity of the 25-CHF2 analog 3 is higher than that of the 1-CHF2 analog 4.

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