Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1992520 | The Journal of Steroid Biochemistry and Molecular Biology | 2007 | 9 Pages |
Abstract
Three new Vitamin D analogs 3–5 incorporating a –CHF2 group as an –OH surrogate have been prepared. Two of these new analogs (3 and 5) are strongly antiproliferative toward murine keratinocytes and are approximately 50 times less calciuric in vivo than the natural hormone calcitriol. The transcriptional activity of the 25-CHF2 analog 3 is higher than that of the 1-CHF2 analog 4.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Gary H. Posner, Byung Chul Suh, Kimberly S. Petersen, Patrick Dolan, Elin S. Agoston, Thomas W. Kensler, John T. Koh, Sara Peleg,