| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1992964 | The Journal of Steroid Biochemistry and Molecular Biology | 2008 | 4 Pages |
Abstract
Degradation of myofibrillar proteins increased from 2.62 ± 0.28 to 5.58 ± 0.49% per day during glucocorticoids excess. Both fibril- and network-forming collagen-specific mRNA levels decreased at the same time in both types of skeletal muscle. Specific mRNA level for MMP-2 did not change significantly during dexamethasone administration. Hindlimb grip strength simultaneously decreased. The effect of excessive glucocorticoids on the extracellular compartment did not differ significantly in skeletal muscles with different twitch characteristics.
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Authors
Eva-Maria Riso, Anne Ahtikoski, Karin Alev, Priit Kaasik, Ando Pehme, Teet Seene,