Long-term effects of an exercise and Mediterranean diet intervention in the vascular function of an older, healthy population

•Cardiovascular disease risk increases significantly with ageing.•Exercise and Mediterranean diet offer cardiovascular benefits in older people.•The need to establish the longer-term intervention benefits persists.•We followed participants, 1 year after the original intervention.•Microvascular benefits were sustained in the Exercise and diet group.

BackgroundPreserving endothelial function and microvascular integrity is suggested to reduce cardiovascular disease risk. It was recently shown that the age-dependent decline in endothelial and microvascular integrity may be reversed when combining exercise with Mediterranean diet (MD) in an 8-week intervention. The present study investigates whether the risk-reduction improvement in microcirculatory and cardiorespiratory functions are sustained in this age-group after a 1-year follow-up.Design and methodsTwenty sedentary healthy participants (age, 55 ± 4 years) from the original study underwent cardiopulmonary exercise tolerance test and were assessed for their upper- and lower-limb vascular endothelial cutaneous vascular conductance (CVC) using laser Doppler fluximetry (LDF) with endothelium-dependent [ACh (acetylcholine chloride)] and endothelium-independent [SNP (sodium nitroprusside)] vasodilation, 1 year after completing the intervention.ResultsBoth MD and exercise groups appeared to have an improved microvascular responses, in comparison to baseline as far as ACh is concerned. Exploring the interactions between the time point and the original group, however, revealed a stronger improvement in the MD group in comparison to the exercise group, for ACh (p = 0.04, d = 0.41). In the upper body, the time point and group interaction for ACh, indicated a better improvement for MD, without however statistical significance (p = 0.07, d = 0.24). Additionally, cardiorespiratory improvement in ventilatory threshold was maintained, 1 year after (12.2 ± 3.0 vs. 13.2 ± 3.2 ml ∙ kg− 1 ∙ min− 1, p < 0.05).ConclusionsThe original improvements from an 8-week exercise and MD intervention were still evident, particularly in the microcirculatory and cardiorespiratory assessments, 1 year after the initial study. This suggests that a brief intervention combining MD with exercise in this high-risk group promises long-term health benefits.