| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1994763 | Microvascular Research | 2014 | 9 Pages |
Abstract
•Markers specific to lymphatic vessels•Neuropilins in development•Neuropilins in disease and cancer•Transgenic and mutant neuropilin mice•Targeting lymphangiogenesis to inhibit metastasis
Metastasis is the leading cause of cancer-related deaths. Understanding how the lymphatic system responds to its environment and local stimuli may lead to therapies to combat metastasis and other lymphatic-associated diseases. This review compares lymphatic vessels and blood vessels, discusses markers of lymphatic vasculature, and elucidates some of the signaling motifs involved in lymphangiogenesis. Recent progress implicating the neuropilin and semaphorin axes in this process is discussed.
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Authors
Matthew T. Migliozzi, Patrick Mucka, Diane R. Bielenberg,