| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1994985 | Microvascular Research | 2011 | 8 Pages |
Abstract
⺠Using a gas-permeable narrow tube (25 µm), NO-binding of HBOCs was observed. ⺠PEGylation, encapsulation, and HES-addition of Hb increase the viscosity. ⺠They retard the NO-binding as compared with an Hb solution. ⺠Addition of HES to Hb-vesicles further retards the reaction to the level of RBCs. ⺠Increased particle size and viscosity might mitigate NO-related vasoconstriction.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Hiromi Sakai, Naoto Okuda, Shinji Takeoka, Eishun Tsuchida,