| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1995011 | Microvascular Research | 2011 | 17 Pages |
Abstract
⺠Glioma CM stimulates phosphorylation of cPLA2, PKCα, and ERK1/2 in ECs. ⺠Glioma CM increased cPLA2 and iPLA2 enzyme activities and expression. ⺠Blockade of cPLA2 and iPLA2 activities with specific antibodies or siRNAs significantly reduces CMstimulated proliferation. ⺠Measurement of PGE2 levels in growth media are correlated with PLA2 activity and PLA2 and COX-2 expression.
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Authors
Giovanni Giurdanella, Carla Motta, Stefano Muriana, Valeria Arena, Carmelina Daniela Anfuso, Gabriella Lupo, Mario Alberghina,