Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1995660 | Molecular Aspects of Medicine | 2014 | 52 Pages |
Abstract
Cardiovascular disease remains the leading cause of morbidity and mortality in the United States and other developed countries, and is fast growing in developing countries, particularly as life expectancy in all parts of the world increases. Current recommendations for the prevention of cardiovascular disease issued jointly from the American Academy of Cardiology and American Heart Association emphasize that lifestyle modification should be incorporated into any treatment plan, including those on statin drugs. However, there is a dearth of data on the interaction between diet and statins with respect to additive, complementary or antagonistic effects. This review collates the available data on the interaction of statins and dietary patterns, cognition, genetics and individual nutrients, including vitamin D, niacin, omega-3 fatty acids, fiber, phytochemicals (polyphenols and stanols) and alcohol. Of note, although the available data is summarized, the scope is limited, conflicting and disparate. In some cases it is likely there is unrecognized synergism. Virtually no data are available describing the interactions of statins with dietary components or dietary pattern in subgroups of the population, particularly those who may benefit most were positive effects identified. Hence, it is virtually impossible to draw any firm conclusions at this time. Nevertheless, this area is important because were the effects of statins and diet additive or synergistic harnessing the effect could potentially lead to the use of a lower intensity statin or dose.
Keywords
ABCEPACmaxCNVCCL2CyPUDP-glycosyltransferaseAHAUGTEGCGU.S.ALAALTHMGCRMCP-1Epigallocatechin-3-gallateLDL-CPPARNCEPHDL-CICAM1tmaxHMG-CoAIL6PLA225OHDHDAC2hsCRPVDBPADRapoA1VDRMDR1LPLVLDL7-DehydrocholesterolCPT2DHCR77-dehydrocholesterol reductaseCDKN3-hydroxy-3-methyl-glutaryl-CoAKIF6FDAVCAM1SREBF21,25(OH)2D1,25-dihydroxyvitamin D25-hydroxyvitamin D3-hydroxy-3-methyl-glutaryl-CoA reductase7-DHCAUCt1/2Alanine aminotransferaseApolipoprotein A-IInteractionStatinalpha-linolenic acideicosapentanoic acidDocosahexanoic acidPolyunsaturated fatty acidPUFAAmerican Heart AssociationUnited Statesinterleukin 6National Cholesterol Education Programcoronary artery diseasecardiovascular diseasechronic kidney diseaseNutrientmaximal plasma concentrationDHACVDDietMediterranean dietFood and Drug AdministrationSODSuperoxide dismutasecytochrome PCognitionCADconfidence intervalLipoprotein lipasevery low density lipoproteinGenome-wide association studiesGWASMultidrug resistance-1area under the concentration–time curvecyclin-dependent kinase inhibitorIntercellular adhesion molecule 1Vascular cell adhesion molecule 1CKDCopy number variantHalf-lifeHistone deacetylase 2Adverse drug reactionsmonocyte chemotactic protein 1Vitamin D binding proteinhigh sensitivity C-reactive proteinC-reactive proteinCRPhigh density lipoprotein cholesterollow density lipoprotein cholesterolATP binding cassettechemokine (C–C motif) ligand 2peroxisome proliferator-activated receptorVitamin D receptor
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Huifen Wang, Jeffrey B. Blumberg, C.-Y. Oliver Chen, Sang-Woon Choi, Michael P. Corcoran, Susan S. Harris, Paul F. Jacques, Aleksandra S. Kristo, Chao-Qiang Lai, Stefania Lamon-Fava, Nirupa R. Matthan, Diane L. McKay, Mohsen Meydani, Laurence D. Parnell,