Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1995695 | Molecular Aspects of Medicine | 2013 | 21 Pages |
Abstract
ADP-ribosylation of proteins regulates protein activities in various processes including transcription control, chromatin organization, organelle assembly, protein degradation, and DNA repair. Modulating the proteins involved in the metabolism of ADP-ribosylation can have therapeutic benefits in various disease states. Protein crystal structures can help understand the biological functions, facilitate detailed analysis of single residues, as well as provide a basis for development of small molecule effectors. Here we review recent advances in our understanding of the structural biology of the writers, readers, and erasers of ADP-ribosylation.
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Authors
Tobias Karlberg, Marie-France Langelier, John M. Pascal, Herwig Schüler,