Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1995797 | Molecular Aspects of Medicine | 2012 | 26 Pages |
Abstract
In this review, we present the currently available knowledge regarding the expression and function of AQPs in the inner ear. We give special consideration to AQP subtypes AQP2, AQP4 and AQP5, which have been studied most extensively. The potential functions of AQP2 and AQP5 in the resorption and secretion of endolymph and of AQP4 in the equilibration of cell volume are described. The pathophysiological implications of these AQP subtypes for inner ear diseases, that appear to involve impaired fluid regulation, such as Menière's disease and Sjögren's syndrome, are discussed.
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Authors
Andreas Eckhard, Corinna Gleiser, Heinz Arnold, Helge Rask-Andersen, Hidetaka Kumagami, Marcus Müller, Bernhard Hirt, Hubert Löwenheim,