| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1996433 | Molecular Cell | 2013 | 12 Pages |
Abstract
⺠cAMP-dependent protein kinase (PKA) serine phosphorylates TFAM within HMG1 ⺠HMG1 phosphorylation of TFAM impairs DNA binding and transcription activation ⺠Lon protease selectively degrades DNA-free TFAM and is inhibited by bortezomib ⺠Lon knockdown stabilizes TFAM in mtDNA-deficient cells and upregulates mtDNA
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Authors
Bin Lu, Jae Lee, Xiaobo Nie, Min Li, Yaroslav I. Morozov, Sundararajan Venkatesh, Daniel F. Bogenhagen, Dmitry Temiakov, Carolyn K. Suzuki,