| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1996602 | Molecular Cell | 2012 | 12 Pages |
Abstract
⺠Glmn binds the RING domain of Rbx1 and inhibits CRL1Fbw7 E3 ligase activity ⺠Glmn null mice phenotype partially mirrors that associated with loss of Fbw7 ⺠GVM Glmn mutants fail to bind Rbx1 leading to deregulation of Fbw7 stability ⺠GVM lesions reflect abnormal homeostasis of Fbw7, Cyclin E, and c-Myc
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Authors
Adriana E. Tron, Takehiro Arai, David M. Duda, Hiroshi Kuwabara, Jennifer L. Olszewski, Yuko Fujiwara, Brittany N. Bahamon, Sabina Signoretti, Brenda A. Schulman, James A. DeCaprio,