Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1996656 | Molecular Cell | 2011 | 15 Pages |
Abstract
⺠The energy-sensing kinase AMPK directly phosphorylates proteins involved in mitosis ⺠The phosphatase regulatory subunit PPP1R12C and the kinase PAK2 are AMPK substrates ⺠AMPK activity and PPP1R12C phosphorylation are particularly high in mitosis ⺠Altering AMPK activity or PPP1R12C phosphorylation impairs proper mitotic completion
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Authors
Max R. Banko, Jasmina J. Allen, Bethany E. Schaffer, Erik W. Wilker, Peiling Tsou, Jamie L. White, Judit Villén, Beatrice Wang, Sara R. Kim, Kei Sakamoto, Steven P. Gygi, Lewis C. Cantley, Michael B. Yaffe, Kevan M. Shokat, Anne Brunet,