| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1996865 | Molecular Cell | 2010 | 12 Pages |
Abstract
⺠DNA damage invokes two signaling axes, triggered by ATM and PARP-1, to activate NF-κB ⺠ATM binds to TRAF6 to induce Ubc13-dependent K63-linked polyUb synthesis ⺠TRAF6 ubiquitination activates TAK1 and cIAP1-dependent IKKγ monoubiquitination ⺠IKKγ-monoUb requires both PARP-1 and ATM signals and is essential for IKK activation
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Authors
Michael Hinz, Michael Stilmann, Seda Ãöl Arslan, Kum Kum Khanna, Gunnar Dittmar, Claus Scheidereit,