| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1996924 | Molecular Cell | 2010 | 13 Pages |
Abstract
⺠Tie1 and Tie2 form a constitutive heterodimeric complex on the cell surface ⺠Tie receptor interactions are inhibitory, attenuating Tie2 catalytic activity ⺠Ang-1 disrupts Tie1-Tie2 complexes, promoting Tie2 clustering and activation ⺠The antagonist, Ang-2, is unable to disrupt Tie1-Tie2 complexes
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Authors
Tom C.M. Seegar, Becca Eller, Dorothea Tzvetkova-Robev, Momchil V. Kolev, Scott C. Henderson, Dimitar B. Nikolov, William A. Barton,