| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1997544 | Molecular Cell | 2007 | 8 Pages |
Abstract
The replication of damaged DNA templates by translesion synthesis (TLS) is associated with mutagenesis and carcinogenesis. This perspective discusses the different levels at which TLS may be controlled and proposes a model for TLS of severely helix-distorting DNA lesions that includes a decisive role for the Rad9-Hus1-Rad1 DNA-damage-signaling clamp. The dual involvement of this clamp in both DNA-damage signaling and TLS may have profound implications in determining cellular responses to DNA damage.
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Authors
Jacob G. Jansen, Maria I. Fousteri, Niels de Wind,